Assignment Example | Topics and Well Written Essays - 2250 words

Assignment ExampleThe santa factor may bind to its precise receptor in the cytosol or on the nuclear membrane. This causes the formation of a receptor-ligand complex that then acts as an effector mite on the DNA ( organization factor or co-factor). This is basically transcription regulation. Several pathways can be implicated. They hold acting as unique(predicate)ity factors, repressors, activators or enhancers. Taking that the santa-receptor complex acts as a repressor for gene transcription this complex may bind to the operator portion of the DNA and prevent the DNA polymerase from transcribing a specific gene, or genes. In the given case, the gene coding for FuIL protein will not be transcribed. The result is that no mRNA is formed, and subsequently no synthesis of the protein. Alternatively, it may act as a post translational modifier. Here, it will modify the folding structure of the FuIL protein, and subsequently lead to the exposure of the degron on the protein for action by ubiquitin conjugating enzymes E1, E2 and E3. Combinations of different ubiquitin-conjugating enzymes and other factors constitute other pathways of the ubiquitin system, each of which conjugates a specific subset of proteins. There is some indicate that certain sequence elements and structural motifs of target proteins are degradation signals which mark them for ubiquitination by a particular model of the ubiquitin system and for eventual degradation. When looking at the santa factor as a direct doer of protein degradation, it may diffuse into the cell and bind to the FuIL protein (like an enzyme-substrate complex) causing a conformational change in its structure that exposes the usually hidden degron. As a ligand, it may also bind to a receptor that catalyzes the phosphorylation forming a phosphodegron which is specific to certain multiunit ubiquitin ligases. An example would be a serpentine receptor. The serpentine receptors are coupled to a blood plasma membrane phosphol ipase C that cleaves PIP2 to diacylglycerol and IP3. By opening calcium channels in the endoplasmic reticulum, IP3 raises cytosolic calcium. Diacylglycerol and calcium act to spark off protein kinase C, which phosphorylates and changes the conformation of the protein. This may be exposure of the degron. This then leads to facilitated function of ubiquitin and proteasome complexes that target and destroy specific proteins. Polyubiquitin tagging of proteins (ubiquitin attachment site in proteins is commonly a lysine side chain) by specific enzymes (E1,2 and 3) provides the major source of selectivity in the process of degradation, whereas the 26S proteasome complex performs the protein unfolding necessary for cleavage of the ubiquitin tagged proteins. This also provides an avenue for selectivity for the FuIL, as the E3 may bind to the santa, become allosterically modified and thus become specific to the FuIL. Such a mechanism is unvarnished where the growth-regulating plant indole a uxin binds to a specific E3 ligase, and forms part of a protein-binding interface that allows high-affinity interaction with specific protein substrates. (Sharon M) ii) Santa Response Element. The santa solution element acts as a secure site for binding of RNA polymerase and the required transcription factors such(prenominal) as the SREB. It thus acts as an operator for the operon in question. The SREB molecule requires transport into the nucleus so as to exert

Reflection on American studies Essay Example | Topics and Well Written Essays - 750 words

Reflection on American studies - Essay ExampleGendering the conversation of globalization reveals the restrictions stuck amid the actualities of womens and mens survive and normal academic work regarding worldwide procedures. Joint with natural concentration to race and racial procedures, gendering ought to construct a enhanced consideration of current worldwide issues. forrader clarifying several of the wide-ranging feminist work that has gendered worldwide investigate and hypothesis, I momentarily size up the thought of sexual category. Sexual category as used here is de delicatelyd as discrimination, split up, and distinction communally rises around assumed difference between feminine and gentleman. Gender is a undeniable classifying standard in communal life, a faith for allotment of responsibility, human rights, rewards, and authority, as well as the resources of fighting. Gender is a issue in arranging daily existence for persons, relatives, throng of people, and civiliz ation as large arrangements. Women are frequently underprivileged in stipulations of authority and substance and rank rewards. Gender is uncomplete a necessary trait of persons nor a stable in communal existence, but consists of objects and figurative features of survivals, infinitely shaped and reproduces in the track of continuing societal actions and performance. The trouble at this time is not oneness of a skilled sentiment missing out. Relatively, it is a pervasive issue in human studies and American studies of point- reluctance to find the paths where the American studies and human studies can easily improve their understand with each other. environ by average genealogy of US-based cultural lessons, national studies and new racially-based studies began from a comparable instant of dominance in the efforts for ethnic and racial civil rights in the 1960s and 1970s, frequently in unity with tertiary World decolonization engagements. More and more, Native American lessons highlights relations connecting Native America and native group of people in the area of the globe, reframing queries of power and native human rights in global conditions whereas continue to remain opinionated conversations of the realm. Such employment decanters paradigms of primary contact with European regal authority and consequent summons by the United States armed and administration that have eclipsed debates of local contact with working class of other origins. Corresponding theories of history as the revision of the history and social evaluation of the life sciences, different ideas regarding the American studies in a disciplinary point of view enforce the results and findings ofAmericancultures understanding in its entirety and the general concepts of American culture at its surroundings. Some authors describes their suggestions at the University of California force of American studies e.g. Jay Mechling, Robert Merideth, and David Wilson, How Jews Became White Folks and what it depicts in American culture, American Jewish narration go into the dialogues. The author conveys the just around the corner as an anthropologist to this energetic combination of literatures transversely obedience. The effect is a fine investigation of the crossroads of

Manchester united brand vision Essay Example | Topics and Well Written Essays - 750 words

Manchester unify brand vision - Essay ExampleThese numbers have become major attractions to the sponsors of the club including AIG, Nike, Chevrolet, Vodafone and so on.A brand represents product development and history (Kotler , Armstrong and Wong, 2008). However, the owner and managers have the power to maintain a brand. Manchester united has a long history of cunning victory matches. The club has owned 19 fusion titles and over 20 other champions. To retain their position, it has to continue acting high level over a long period. Moreover, the club was established over 100 years ago, thereby gaining global fan bases. Therefore, the fans endure to tie their love for the club by purchasing Manchester United costumes, equipment and other accessories. This makes Manchester United as an attractive proposition in the international marketplace.Sponsorship allows inclusion of the company brand logo on the Manchester United conveying kit, the right to use the club logo in promotions a nd advertisements at the Manchester United games (Beech and Chadwick , 2007). It also allows the sponsors to feature in the Manchester United marketing materials such as magazine, internet and program matches. The association with the club will play a significant role to the sponsor brand. These benefits include promoting and enhancing the sponsor brand, there retaining and attracting new customers.The fans and the supporter of Manchester United are the core attribute of its brand. This is an added advantage to the brand over other football clubs because it is regarded as an wound up bond. As a result, Manchester United brand is growing scurrying than other sport brands. It is growing faster and further beyond other traditional sport brands worldwide. Research indicates that the club customer database is over 10 million and, it is forecasted to continue growing (Lagae, 2005).Manchester United is referred to as a distributor brand due to its characteristics and attributes. It has s ponsors from dissimilar

The Image Narrative Research Paper Example | Topics and Well Written Essays - 1250 words

The Image Narrative - Research Paper ExampleManga workman Mizuki Shigeru (b. 1922), creator of the famous supernatural series GeGeGe no Kitaro, is one individual who could not be damned for feeling the likes of a victim.1 In fact, Shigeru lost his left arm in the fight but sees himself, it seems, reflected through his art in the way that the war was torturous and terrible. The key players in the textual matter include Nipponese officials, as well as one character we see throughout the panels. They atomic number 18 both parodied, and the character guiding one through the panels who is the main character acts as though he knows nothing about WWII. The sketch character which is parodied in the panel definitely adds to the general tone of the piece, big(a) War and Japan a slightly humorous bent, although little about War and Japan is real humorous. The topic of the cartoon is whipping, massacre, disaster, and warat their worst. The suffering of the Japanese people is aptly po rtrayed in this graphic cartoon, bringing the reader to a very dark place. In this sense, it is understood why the cartoon is offensive to some people, both to the Japanese and those who are not Japanese. This cartoon disturbs the reader, but with an overall object to educatenot just to shock. That is the redeeming value of this cartoon, is that it seeks to educate its readers about the horrors of war as it relates to Japanese history, pre- and post-World War II. This cartoon exemplifies the suffering of the Japanese in different eras, that is supposed to enlighten the reader as to why the Japanese have a certain mindset regarding the war and its effects. III. Second Set of Questions (150 words) Images counter each other in this piece in the sense that violence mirrors itself continually through the piece, not only talking about the Nanking Massacrebut contrasting that with the atomic bomb that dropped on Hiroshima and the carnage that resulted in that. Not only that but, we see t he overlap and evolution of soldiers having been sent off to the South pacific and Burma from Japan to fight in WWII, an often unseen added element about the War that Shigeru sheds light upon. The images are fixed in terms of being frozen in time, but there is definitely a sense of movement in the images, giving oneself an idea that it is like watching a little depiction of World War II from a Japanese viewpoint. The images are more(prenominal) ambiguous when it comes to larger overviews, like the Nanking Massacre and one jungle scenes seen later in the panel. IV. Third Set of Questions (600 words) Sensory stimulation is paramount to War and Japan. The rhythm and pacing is switched up. At first, Shigeru shows us graphic images, and then gives our eyes a perch between graphic images to process what we have just seen, and then the cartoon character narrator tries to condone what is going on in the mind of ordinary Japanese people, bringing the reader back to a sense of normalcyr ight before the next image is proffered on-screen. The larger pattern of movement overall is a wax and wane, bringing us in peaks and valleys to a crescendo of realizing what it means to be a true Japaneseto stand tall. In this way, the progression from panel to panel is very cyclical, nonlinear, and evocative of an mad rollercoaster in which Shigeru engages us. The turning point of the entire cartoon, if it can be called thatsince one usually thinks of cartoons as more humorous than grotesqueis the massacre that occurs after the Manchu people are worked like slaves

Colonial America between 1492-1763 Essay Example | Topics and Well Written Essays - 1000 words

Colonial America between 1492-1763 - Essay ExampleKing Philips War, also known as Metacoms Rebellion, a war between the colonists of New England and the versatile tribes of the environ areas, was but one example of the clash of cultures between Native Americans and Europeans however, it is significant in history as a clash of cultures for a number of reasons, including its number of casualties, the fact that there were no clear divisions along cultural lines, and that it marked the end of hope that the Native American could be integrated into European conjunction in the New World. In 1675, the Wampanoag chief Metacom resolved to drive the settlers out of what he saw as his land. His father, Massasoit, had ruled with gentle wisdom during his time as sachem (chief) of the Wampanoag, going so far as to befriend the settlers and set up trade with them, but Metacom saw things differently.3 It was up to him, he felt, to drive the settlers rancid his lands, or else he would one day be l eft with nothing.4 He told European authorities really simply, I am determined not to live until I have no country.5 The precede years of peace and harmony, of trade and prosperity between settlers and Native Americans were quickly coming to an end. Ironically, this great difference of opinion was almost avoided. A man by the name of John Sassamon, who had grown up as a Wampanoag but attended Harvard College where he had been given his English name, warned the governor of Plymouth Colony that Metacom had sent word to various tribes to gather and attack.6 Sassamon pleaded with the governor to be allowed to stay at Plymouth Colony, fearing revenge for his warning the governor heartily disregard him and sent him back to his tribe.7 This action would prove to be dire in starting the conflict between the two cultures. It did not take long for hostilities to come to a climax. Sassamon was discovered a week later, his luggage compartment found in a frozen pond with the neck broken.8 T he governor was alarmed, and recalling the warnings he had been given, decided to bank his authority over the Native Americans.9 When he received reports that it was two Wampanoag warriors that had been seen murdering Sassamon, he entered the village of Metacom, dragged the warriors back to Plymouth Colony, and had them time-tested and executed in short order.10 To Metacom, this was seen as a gross injustice of his power, and only(prenominal) served to reinforce his tone that the settlers intended one day to take over both his tribe and all lands.11 Revenge was the only option left, and therefore, it was the option that was taken. The attacks began immediately. First to fall was the southwestern Plymouth settlement of Swansea, which was quickly burned and the settlers driven off. 12 Over the next months, Metacom took his war to various tribes and settlements all close to New England.13 Skirmishes and battles erupted within Massachusetts, Rhode Island, and Connecticut, with trib es rallying around both sides.14 More than twenty towns and settlements were attacked in Massachusetts alone.15 It would not be an exaggeration to say that everyone had chosen sides, both settler and Native